Dried Blood Spot Test Estimation of Urea

Estimation of blood phenylalanine from a dried blood spot using the Guthrie test.

Estimation of genetic risk for Type 1 diabetes mellitus in newborns on dried blood spot.

BACKGROUND The main contribution to genetic susceptibility for Type 1 Diabetes Mellitus (T1DM) is conferred by the Human Leukocyte Antigens (HLA). AIM We evaluated the feasibility of large scale screening on Dried Blood Spot (DBS) to estimate the genetic risk for T1DM in newborns. SUBJECTS AND METHODS Peripheral blood DBS samples from 256 newborns, were genotyped for HLA DRB1 and DQB1 allel...

Measurement of Creatinine from Dried Blood spot by Enzymatic Method

Background: DBS on filter paper has been shown as a feasible matrix for collection, transport and analysis of biochemical analytes. Creatinine, is used as a marker of renal function and staging chronic kidney disease (CKD), often requiring repeated testing for drug dosing in patients who undergo dialysis or those who have had arenal transplant. Blood collected and dried on filter paper would be...

Stability of Proteins in Dried Blood Spot Biobanks*□S

An important motivation for the construction of biobanks is to discover biomarkers that identify diseases at early, potentially curable stages. This will require biobanks from large numbers of individuals, preferably sampled repeatedly, where the samples are collected and stored under conditions that preserve potential biomarkers. Dried blood samples are attractive for biobanking because of the...

Clinical evaluation of a dried blood spot assay for atazanavir.

Current procedures for obtaining and measuring plasma concentrations of HIV protease inhibitors (PIs) are technically challenging. Dried blood spot (DBS) assays offer a way to overcome many of the obstacles. We sought to develop a DBS assay for quantitation of the PI atazanavir (ATV) and to compare this method with a previously validated plasma assay. We prospectively enrolled 48 patients with ...